All keyboard and controller bindings can be customized from the mod settings menu (Ctrl+M, LT+Start/L2+Options).
You can press F1 (LT+Back/L2+Create) at any time to see context-sensitive help showing all controls available on the current screen.
| Action | Keyboard | Controller | Function |
| Navigate | Arrow keys | D-pad/Left Stick | Navigate game screens |
| Navigate Buffers | Ctrl+Arrow keys | Right Stick | Navigate buffers or the map view cursor |
| Select | Enter | A/X | Click UI elements and confirm some popups |
| Cancel | Backspace | B/Circle | Cancel some popups or go back |
| Pause | Escape | Start/Options | Pause menu (in-game), save slots (main menu) |
| Accept | E | Y | End turn, confirm selected cards, confirm some popups |
| Top Panel | T | X/Square | Navigate to top panel (relics/potions), jump to first available epoch in timeline |
| Peek | Space | Left Stick Click | Visually see some obscured screens through others, not useful if using screen reader |
| Action | Keyboard | Controller | Function |
| View Draw Pile | A | LT+LB | View draw pile |
| View Discard Pile | S | RT+RB | View discard pile |
| View Deck / Tab Left | D | LB | View deck, tab left on screens with tabs, decrease ascension level |
| View Exhaust / Tab Right | F | RB | View exhaust pile, tab right on screens with tabs, increase ascension level |
| View Map | M | Back | Open map screen |
| Action | Keyboard | Controller | Function |
| Previous Point of Interest | , (comma) | LT+Right Stick Left | Jump to previous point of interest |
| Next Point of Interest | . (period) | LT+Right Stick Right | Jump to next point of interest |
| Toggle POI Mode | \ (backslash) | LT+Right Stick Up | Toggle between reachable and all points of interest |
| Toggle Marker | / (slash) | — | Mark or unmark the current map node |
| Clear All Markers | Ctrl+Shift+/ | — | Remove all map markers |
| Action | Keyboard | Controller | Function |
| Announce Gold | Ctrl+G | RT+A/R2+X | Announce current gold |
| Announce HP | Ctrl+H | LT+A/L2+X | Announce current HP |
| Announce Block | Ctrl+B | LT+B/L2+Circle | Announce current block |
| Announce Energy | Ctrl+Y | LT+X/L2+Square | Announce current energy |
| Announce Powers | Ctrl+P | LT+Y/L2+Triangle | Announce active powers |
| Announce Intents | Ctrl+I | RT+Y/R2+Triangle | Announce enemy intents |
| Announce Summarized Intents | Alt+I | RT+X/R2+Square | Announce summarized enemy intents |
| Announce Boss | Ctrl+N | RT+B/R2+Circle | Announce current act boss |
| Announce Relic Counters | Ctrl+R | RT+Back/R2+Create | Announce relic counter values |
| Combatant Status 1-12 | 1-0, -, = | — | Announce status of combatant by position |
| Combatant Intent 1-12 | Shift+1-0, Shift+-, Shift+= | — | Announce intent of combatant by position |
| Action | Keyboard | Controller | Function |
| Help | F1 | LT+Back/L2+Create | Show context-sensitive help for current screen |
| Mod Settings | Ctrl+M | LT+Start/L2+Options | Open mod settings menu |
| Toggle Accessibility | Ctrl+Shift+A | — | Requires game restart |
| Reset Bindings | Ctrl+Shift+R | — | Reset all mod keybindings to defaults |